A CPC-SHELTERIN-BTR AXIS REGULATES MITOTIC TELOMERE DEPROTECTION

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Abstract Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and super-resolution imaging, we

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Echocardiographic follow-up to right ventricular modifications in secondary pulmonary hypertension to diabetes in rats

Clinical studies suggest that diabetes is a risk factor in the development of pulmonary arterial hypertension.The increase in blood pressure in the pulmonary area is characterized by the increase in the afterload and hypertrophy of the right ventricle.The objective of this study was to conduct a longitudinal follow-up Ferrite Bead of the morphologi

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Regulating Effects of Dietary Fiber and Powder of Agaricus bisporus Based on in Vitro Fermentation on Human Gut Microbiota

Objective: To explore the regulating function of the dietary fiber of Agaricus bisporus and the powder of Agaricus bisporus on the human gut microbiota.Methods: Dietary fiber of Agaricus bisporus were extracted by water extraction and alcohol precipitation for human gut microbial fermentation in vitro.The pH, gas production and short-chain fatty ac

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